Introducing GlucodOX®— the only patented guggul-based nutraceutical for stimulating AMPK to support metabolic health and wellness.
Extends your “healthspan” by enhancing the body’s response to cellular and metabolic stress:
Most guggulsterones support normal lipid (cholesterol) and glucose (diabetes) metabolism. By stimulating AMPK, the patented formulation in GlucodOX takes guggulsterones further, adding longevity-promoting mechanisms much like metformin.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. References: 1. Data on file. Nutent Therapeutics. 2. Claudel T, Staels B, Kuipers F. The farnesoid X receptor: a molecular link between bile acid and lipid and glucose metabolism. Arterioscler Thromb Vasc Biol. 2005;25(10):2020-2030. 3. Lage R, Dieguez C, Vidal-Puig A, Lopez M. AMPK: a metabolic gauge regulating whole-body energy homeostasis. Trends Mol Med. 2008;14:539-549. 4. Long YC, Zierath JR. AMP-activated protein kinase signaling in metabolic regulation. J Clin Invest. 2006;116:1776-1783. 5. Steinberg GR, Kemp BE. AMPK in health and disease. Physiol Rev. 2009;89:1025-1078. 6. Hardie DG, Hawley SA, Scott JW. AMP-activated protein kinase–development of the energy sensor concept. J Physiol. 2006;574:7-15. 7. Stayrook KR, Bramlett KS, Savkur RS, Ficorilli J, et al. Regulation of carbohydrate metabolism by the farnesoid X receptor. Endocrinology. 2005;146(3):984-991. 8. Lim CT, Kola B, Korbonits M. AMPK as a mediator of hormonal signaling. J Mol Endocrinol. 2010;44:87-97. 9. Osler ME, Zierath JR. Adenosine 5’-monophosphate-activated protein kinase regulation of fatty acid oxidation in skeletal muscle. Endocrinology. 2008;149:935-941. 10. Sharma B, Salunke R, Srivastava S, Majumder C, Roy P. Effects of guggulsterone isolated from Commiphora mukul in high fat diet induced diabetic rats. Food Chem Toxicol. 2009; 47(10):2631-2639. 11. Yang JY, Della-Fera MA, Baile CA. Guggulsterone inhibits adipocyte differentiation and induces apoptosis in 3T3-L1 cells. Obesity. 2008;16:16-22. 12. Rizzo G, Disante M, Mencarelli A, et al. The farnesoid X receptor promotes adipocyte differentiation and regulates adipose cell function in vivo. Mol Pharmacol. 2006;70:1164-1173. 13. Nityanand S, Srivastava JS, Asthana OP. Clinical trials with gugulipid. A new hypolipidaemic agent. J Assoc Physicians India. 1989;37:323-328. 14. Gopal K, Saran RK, Nityanand S, et al. Clinical trial of ethyl acetate extract of gum gugulu (gugulipid) in primary hyperlipidemia. J Assoc Physicians India. 1986;34:249-251. 15. Agarwal RC, Singh SP, Saran RK, et al. Clinical trial of gugulipid–a new hypolipidemic agent of plant origin in primary hyperlipidemia. Indian J Med Res. 1986;84:626-634. 16. Cantó C, Gerhart-Hines Z, Feige JN, et al. AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity. Nature. 2009;458:1056-1060. 17. Urizar NL, Liverman AB, Dodds DT, et al. A natural product that lowers cholesterol as an antagonist ligand for FXR. Science. 2002;296:1703-1706. 18. Salminen A, Kaarniranta K, Kauppinen A. Age-related changes in AMPK activation: role for AMPK phosphatases and inhibitory phosphorylation by upstream signaling pathways. Ageing Res Rev. 2016;28:15-26. 19. Salminen A, Kaarniranta K. AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network. Ageing Res Rev. 2012;11:230-241. 20. Yang JY, Della-Fera MA, Rayalam S, Ambati S, Baile CA. Enhanced pro-apoptotic and anti-adipogenic effects of genistein plus guggulsterone in 3T3-L1 adipocytes. Biofactors. 2007;30:159-169. 21. Ramachandran C, Nair SM, Quirrin K-W, Melnick, SJ. Hypolipidemic effects of a proprietary Commiphora mukul gum resin extract and medium-chain triglyceride preparation (GU-MCT810). J Ev Comp Alt Med. 2013;18(4):248-256. https://doi. org/10.1177/2156587213488601. 22. Kunnumakkara AB, Banik K, Bordoloi D, et al. Googling the guggul (commiphora and boswellia) for prevention of chronic diseases. Front Pharmacol. 2018;9:686. doi:10.3389/fphar.2018.00686. 23. Dev S. Ethnotherapeutics and modern drug development: the potential of ayurveda. Curr Sci. 1997;73(11): 909-928. www.jstor.org/stable/24101288.